Devyser Extend

Devyser Extend is a new, unique, QF-PCR kit for aneuploidy analysis of chromosomes 13, 15, 16, 18, 21, 22 X and Y.

Women who have undergone one or more spontaneous abortions caused by chromosomal abnormalities are at increased risk for chromosomal abnormalities in future pregnancies. Cytogenetic studies of miscarriages are highly recommended even in the case of the first spontaneous abortion. Identification of the possible cause of fetal loss significantly reduces long-term psychological distress in women with a miscarriage and enables improved genetic counseling for those couples in future pregnancies. The most frequently observed numerical chromosomal abnormalities involve chromosomes 13, 15, 16, 18, 21, 22 and X.

Conventional cytogenetic studies (karyotyping or FISH) are expensive and need a long period of time in order to obtain results. Moreover, they result in high rates of culture failure, misdiagnosis due to maternal contamination and cell overgrowth as well as insufficient quality of chromosome preparations. Cell culture may selectively yield normal karyotypes or selected abnormal karyotypes that survive in-vitro cell proliferation

QF-PCR does not require cell culture, requires minute amounts of tissue material and allows the lab to obtain results within one working day. The Devyser Extend kit includes 40 STR markers for aneuploidy analysis by QF-PCR of chromosomes 13, 15, 16, 18, 21, 22, X and Y.

Avaliable kit configurations, Devyser Extend:
Devyser Extend, Art.# 8-A015: including three separate PCR mixes for detection of aneuploidies in chromosomes 13, 15, 16, 18, 21, 22, X and Y. Kit size: 25 tests/kit

Devyser Extend M1, Art.# 8-A015-M1: includes one unique PCR mix for detection of aneuploidies in chromosomes 15, 16 and 22. Kit size: 25 tests/kit