RHD screening just got easier: how single exon NIPT testing helps

In RhD-negative mothers, anti-D prophylaxis can be withheld if the fetus is also RhD-negative. Fetal RHD status testing with NIPT is efficient and low risk. Single exon kits are a simple, accurate, and cost-effective RHD screening solution.

RhD incompatibility between mother and fetus is the most common and only preventable cause of fetal and neonatal hemolytic disease (HDFN). Since the introduction of anti-RhD prophylaxis in the 1960s, the prevalence has decreased significantly. In many countries treatment is given to all RhD-negative mothers to prevent alloimmunization. However, 40% of these women carry an RhD-negative fetus, making prophylaxis an overtreatment. Determination of fetal RHD status allows us to optimize anti-RhD administration without risking an increase in hemolytic disease.

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RHD screening just got easier: how single exon NIPT testing helps

In RhD-negative mothers, anti-D prophylaxis can be withheld if the fetus is also RhD-negative. Fetal RHD status testing with NIPT is efficient and low risk. Single exon kits are a simple, accurate, and cost-effective RHD screening solution.

RhD incompatibility between mother and fetus is the most common and only preventable cause of fetal and neonatal hemolytic disease (HDFN). Since the introduction of anti-RhD prophylaxis in the 1960s, the prevalence has decreased significantly. In many countries treatment is given to all RhD-negative mothers to prevent alloimmunization. However, 40% of these women carry an RhD-negative fetus, making prophylaxis an overtreatment. Determination of fetal RHD status allows us to optimize anti-RhD administration without risking an increase in hemolytic disease.