Rapid aneuploidy analysis

Fast, precise and cost-effective chromosomal aneuploidy analysis with QF-PCR technology. Results within one working day.

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3 Pink
Devyser Compact
Detects chromosomal aneuploidies and maternal cell contamination (MCC)
Single-tube PCR
Fast analysis with minimum hands-on time
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2 Purple
Devyser Complete
Rapid prenatal aneuploidy analysis of chromosomes 13, 18, 21, X and Y
No tissue culture needed
Aneuploidy analysis using 33 genetic markers
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1 Apricot
Devyser Extend
Rapid aneuploidy analysis of chromosomes 13, 15, 16, 18, 21, 22, X and Y
Results in less than 5 hours
No tissue culture required
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3 Pink
Devyser Resolution 13
Rapid prenatal aneuploidy analysis of chromosome 13
Requires minimal amounts of genomic DNA
Results in less than five hours
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1 Medium
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Devyser Resolution 18
Rapid prenatal aneuploidy analysis of chromosome 18
Requires minimal amounts of genomic DNA
Results in less than five hours
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1 Medium
3 Pink
Devyser Resolution 21
Rapid prenatal aneuploidy analysis of chromosome 21
Requires minimal amounts of genomic DNA
Results in less than five hours
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1 Medium
3 Pink
Devyser Resolution XY
Rapid aneuploidy analysis of chromosomes X and Y
Requires minimal amounts of genomic DNA
Results in less than five hours
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Rapid aneuploidy analysis

Fast, precise and cost-effective chromosomal aneuploidy analysis with QF-PCR technology. Results within one working day.

Advantages of QF-PCR

Analysis using QF-PCR can be performed on a minimal amount of tissue material, does not require cell culture and enables the lab to obtain results within one working day. Other advantages include efficient and sensitive detection of chromosomal aneuploidies and maternal cell contamination (MCC) in DNA samples prior to microarray analysis. It also enables reliable detection of Turner syndrome through the use of unique X-chromosome counting markers.

Rapid prenatal aneuploidy analysis

In pregnancies associated with an elevated risk of aneuploidy, genetic prenatal diagnosis can be performed through chorionic villus sampling or amniocentesis. Common indications for genetic prenatal diagnosis include a positive multiple biochemical marker screen, a high-risk result on noninvasive prenatal testing (NIPT), and abnormal ultrasound findings.

QF-PCR is useful for rapid aneuploidy detection, and is increasingly being used in prenatal diagnostics due to its ability to provide information in a cost-effective and timely manner. Due to its accuracy and rapid turnaround time, QF-PCR is the most popular first line test in genetic prenatal diagnosis of pregnancies at increased risk of aneuploidy of chromosomes 13, 18, 21, X, or Y.

Rapid pregnancy loss analysis

Women who have undergone one or more spontaneous abortions caused by chromosomal abnormalities are at increased risk for chromosomal abnormalities in future pregnancies. Cytogenetic studies of miscarriages are highly recommended even in the case of the first pregnancy loss. Identification of the possible cause of fetal loss significantly reduces the long-term psychological distress associated with a miscarriage and enables improved genetic counseling in future pregnancies. The most frequently observed numerical chromosomal abnormalities involve chromosomes 13, 15, 16, 18, 21, 22 and X.

Related articles

Whitepaper: Introduction to QF-PCR by Dr. Kathy Mann

Whitepaper: Detecting Mosaicism with QF-PCR by Dr. Kathy Mann

Whitepaper: QF-PCR and Maternal Cell Contamination by Dr. Kathy Mann

Whitepaper: QF-PCR in Pregnancy Loss Analysis by Dr. Helen White

Scientific publications

Adrenoleukodystrophy NewbornScreening in the Netherlands (SCAN Study): The X-Factor. Barendsen et al., Front.Cell Dev. Biol., 17 June 2020

Abnormal non‐invasive prenatal test results concordant withkaryotype of cytotrophoblast but not reflecting abnormal fetal karyotype. M. I.Srebniak et al., Ultrasound in Obstetrics & Gynecology, 2014, Volume 44, Issue 1p. 109-111

Chromosome aberrations in a largeseries of spontaneous miscarriages in the German population and review of theliterature. Jutta Jenderny. Mol Cytogenet. 2014; 7: 38

Use of a DNA method, QF-PCR, inthe prenatal diagnosis of fetal aneuploidies. Langlois S., Duncan A. J ObstetGynaecol Can. 2011 Sep;33(9):955-960

Assessment of QF-PCR as the first approach in prenataldiagnosis. Badenas C. et al., J MolDiagn. 2010 Nov;12(6):828-34.

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