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Devyser CFTR Core

Allele-specific genotyping of a panel of normal and mutated alleles in the CFTR gene common in the European population.

  • Detects the 36 most common mutations found in populations of European origin
  • Allele-specific detection of wild-type and variants

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Devyser CFTR Core

Allele-specific genotyping of a panel of normal and mutated alleles in the CFTR gene common in the European population.

  • Detects the 36 most common mutations found in populations of European origin
  • Allele-specific detection of wild-type and variants

A complete CFTR kit for first level mutation screening

The Devyser CFTR Core kit is designed to genotype the normal and mutant alleles at 33 loci of the CFTR gene using purified human genomic DNA. Genotype coverage includes a panel of 36 mutations common in multiethnic European populations.The assay also detects poly-thymidine variants (5T/7T/9T) within intron 9(IVS8) of the CFTR gene. In case of a 5T allele, the TG repeat number upstream of the poly-T region can also be determined. The Devyser CFTR Core kit is based on multiplex allele-specific PCR amplification for detection of normal, non-mutated and mutated alleles in the CFTR gene. Allele-specific PCR amplification generates fluorescently labelled fragments that are analyzed by capillary electrophoresis on a Genetic Analyzer instrument. Amplified fragments are identified based on size and fluorescent labels.

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Product Details

CE-IVD

Devyser CFTR Core
Detection of the following CFTR mutations: 711+1G>T, 3120+1G>A, 621+1G>T, 1717-1G>A, CFTRdele2,3(21kb), 3849+10kbC>T, 2789+5G>A, 1898+1G>A, G542X, G85E, Y1092X(C>A), G551D, R553X, 3659delC, N1303K, R560T, R117H, R1162X, L1077P, R117C, R1066C, L1065P, W1282X, R347H, R347P, I507del, T338I, F508del, I336K, 1677delTA, R334W, 3272-26A>G, 1078delT, 2183AA>G, 2184insA, 2143delT and corresponding wildtype alleles. IVS8: 5T (including identification of TG9-13), 7T, 9T. Calibrated with DEV-5.
8-A031
Pack size: 
48

RUO

Devyser CFTR Core
Detection of the following CFTR mutations: 711+1G>T, 3120+1G>A, 621+1G>T, 1717-1G>A, CFTRdele2,3(21kb), 3849+10kbC>T, 2789+5G>A, 1898+1G>A, G542X, G85E, Y1092X(C>A), G551D, R553X, 3659delC, N1303K, R560T, R117H, R1162X, L1077P, R117C, R1066C, L1065P, W1282X, R347H, R347P, I507del, T338I, F508del, I336K, 1677delTA, R334W, 3272-26A>G, 1078delT, 2183AA>G, 2184insA, 2143delT and corresponding wildtype alleles. IVS8: 5T (including identification of TG9-13), 7T, 9T. Calibrated with DEV-5. Calibrated with DEV-5.
8-A031-RUO
Pack size: 
48