Devyser Thalassemia NGS

A single, one-tube NGS assay that detects all sequence variants in HBA1, HBA2 and HBB in a single run, eliminating the need for additional workflows. The assay detects SNVs, Indels and applies two simultaneous methods to detect CNVs. The extremely simple procedure suits any lab, whether you are running advanced genetic testing or large scale mutation screening.

Complete single-tube analysis for thalassemias
Fast and simple NGS workflow
User-friendly data analysis software

Simple procedure to detect all mutations in HBA1, HBA2 & HBB

With the Devyser Thalassemia kit you can detect all mutations in HBA1, HBA2 and HBB using a single, one-tube NGS assay.

The assay detects single nucleotide polymorphisms (SNVs) Indels and CNVs. The extremely simple procedure makes it an excellent choice for any lab, whether you are running advanced second level genetic testing or large scale mutation screening.

The fast, simple and robust NGS workflow replaces complex multi-step protocols and eliminates the need for maintaining multiple Thalassemia assays in your lab.

Comprehensive CNV detection

Devyser’s proprietary PCR chemistry provides complete and uniform coverage of the relevant genetic regions by enabling a high level of overlapping amplicon multiplexing.

This simple workflow significantly reduces the risk for contamination and sample mix-up. Reliable detection of large structural deletion is further improved through the use of PCR primers aligned to both ends of 18 large deletions with high prevalence. Simultaneously, coverage based CNV analysis is used to confirm detected deletions and to identify additional large structural deletions in the targeted regions.