A new NGS-based method for Chimerism monitoring

Download whitepaper

A new NGS-based method for Chimerism monitoring

The Karolinska Hospital in Huddinge is home to Sweden’s only specialized clinic for allogenic stem cell transplantations (CAST) and performs more transplantations than any other hospital in Sweden. It treats Swedish and international patients with malignant haematological diseases, anemia and immunodeficiency diseases as well as certain metabolic diseases. The specialized clinic also performs advanced cell therapy for cancers such as lymphomas and leukemias (Car-T).

“ The pace of diagnostic innovation is extremely high today, and chimerism is no exception. New, highly sensitive and precise methods can significantly increase patient survival as well as reduce costs for the laboratory. As Medical Director of the Transplantation Immunology Laboratory it is my responsibility to not only ensure that we leverage the best diagnostic technologies, but also to help the clinicians find the gold dust in the massive amounts of emerging research and translate this into actionable information that will help save lives.” said Dr. Dan Hauzenberger, Medical Director, Section of Transplantation Immunology at Sweden’s Karolinska University Hospital

Research is an integrated part of this clinic since more than four decades, resulting in a vast number of scientific publications with focus on managing complications such as Graft vs. Host Disease, infections and disease relapse.

The highly specialized Transplantation Immunology Laboratory supports the transplantation teams at Karolinska. The laboratory follows each patient throughout the entire transplantation process, from finding a suitable stem cell donor, pre-transplantation tissue typing to post-transplantation chimerism monitoring.